The 20S proteasome processes NF-κB1 p105 into p50 in a translation-independent manner
نویسندگان
چکیده
منابع مشابه
The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner.
The NF-kappaB p50 is the N-terminal processed product of the precursor, p105. It has been suggested that p50 is generated not from full-length p105 but cotranslationally from incompletely synthesized molecules by the proteasome. We show that the 20S proteasome endoproteolytically cleaves the fully synthesized p105 and selectively degrades the C-terminus of p105, leading to p50 generation in a u...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2006
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7601081